Handgrip Strength Is Associated with Specific Aspects of Vascular Function in Individuals with Metabolic Syndrome.

BACKGROUND: Metabolic syndrome (MetS) is a disorder associated with an increased risk for the development of diabetes mellitus and its complications. Lower isometric handgrip strength (HGS) is associated with an increased risk of cardiometabolic diseases. However, the association between HGS and arterial stiffness parameters, which are considered the predictors of morbidity and mortality in individuals with MetS, is not well defined. OBJECTIVE: To determine the association between HGS and HGS asymmetry on components of vascular function in adults with MetS. METHODS: We measured handgrip strength normalized to bodyweight (HGS/kg), HGS asymmetry, body composition, blood glucose, lipid profile, blood pressure, pulse wave velocity (PWV), reflection coefficient (RC), augmentation index @75 bpm (AIx@75) and peripheral vascular resistance (PVR) in 55 adults with a diagnosis of MetS between 25 and 54 years old. RESULTS: Mean age was 43.1 ± 7.0 years, 56.3% were females. HGS/kg was negatively correlated with AIx@75 (r = -0.440), p < 0.05, but these associations were not significant after adjusting for age and sex. However, when interaction effects between sex, HGS/kg and age were examined, we observed an inverse relationship between HGS/kg and AIx@75 in the older adults in the sample, whereas in the younger adults, a weak direct association was found. We also found a significant association between HGS asymmetry and PVR (beta = 30, 95% CI = 7.02; 54.2; p <0.012). CONCLUSIONS: Our findings suggest that in people with MetS, maintaining muscle strength may have an increasingly important role in older age in the attenuation of age-related increases in AIx@75-a marker of vascular stiffness-and that a higher HGS asymmetry could be associated with a greater vascular resistance.

Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week.

Isometric handgrip or (wall) squat exercise performed three times per week produces reductions in systolic blood pressure (SBP) in adults with hypertension. We aimed to compare these interventions and the potential to retain benefits with one exercise session per week. We compared blood pressure changes following handgrip and squat isometric training interventions with controls in a randomized controlled multicentre trial in 77 unmedicated hypertensive (SBP ≥ 130 mmHg) adults. Exercise sessions were performed in the workplace and consisted of four repetitions-three sessions per week for the first 12 weeks (phase 1), and one session per week for the subsequent 12 weeks (phase 2). Office blood pressure (BP) was measured at baseline, post-phase 1 and post-phase 2. Post-phase 1, mean reductions in SBP were significantly greater in handgrip (-11.2 mmHg, n = 28) and squat (-12.9 mmHg, n = 27) groups than in controls (-.4 mmHg; n = 22) but changes in DBP were not. There were no significant within-group changes during phase 2 but SBP was 3.8 mmHg lower in the wall squat than the handgrip group-a small magnitude but clinically important difference. While both interventions produced significant SBP reductions, the wall squat appears to be more effective in maintaining benefits with a minimal training dose. The low time investment to achieve and retain clinically significant SBP reductions-42 and 12 min, respectively-and minimal cost, particularly of the wall squat, make it a promising intervention for delivery in public health settings.

Calidad de vida y adherencia al tratamiento de personas con enfermedad crónica oncológica / Quality of life and adherence to treatment on people with chronic oncologic disease

Introducción: La experiencia del cáncer afecta las dimensiones de la Calidad de vida (CV); la adherencia al tratamiento oncológico es un asunto poco descrito en la literatura científica, sin embargo, éste puede guardar relación con la calidad de vida de personas con enfermedad crónica oncológica, sobre todo en los primeros meses del diagnóstico. Materiales y Métodos: Estudio descriptivo, de correlación, cuantitativo y corte transversal. Participaron 158 personas con enfermedad crónica oncológica diagnosticadas entre 0 y 6 meses que asisten a una institución de tercer nivel de atención en salud de Bucaramanga, Colombia. Se aplicó la Escala de Calidad de vida versión paciente y el Instrumento para Evaluar los Factores que Influyen en la Adherencia a los Tratamientos Farmacológicos y no Farmacológicos en Pacientes con Riesgo de Enfermedad Cardiovascular. Para el análisis se utilizó estadística descriptiva y coeficiente de correlación lineal de Pearson.Resultados: La muestra, mayoritariamente mujeres, mayores de 60 años, de estratos bajos, dedicadas al hogar, principalmente con cáncer de mama, cérvix, piel; se observó analfabetismo en el 15%. La CV mostro media de 104.17 (DE 16.71). El 51% se ubicó en bajo riesgo y 41.75 riesgo medio para no adherirse. Se encontró relación débil positiva entre las dos variables r=,232 p=0,003. Discusión: La correlación lineal entre las dos variables en los pacientes con cáncer es menor que la descrita en estudios de otras condiciones de enfermedades crónicas no trasmisibles y crónicas infecciosas. Conclusiones: Hay relación débil entre la CV y los grados de riesgo para la adherencia al tratamiento y de las mismas con las dimensiones de cada variable.

Introduction: Cancer experience affects the dimensions of quality of life; the adding of an oncological treatment is a matter that has not been described in the scientific literature, however this aspect can be related to the levels quality of life of the people suffering from chronic oncologic diseases, mainly during the first months of diagnosis. Materials and Methods: Correlative descriptive research, quantitative boarding and cross-cutting. 158 participants with chronic diseases that were diagnosed with a life expectancy between 0 and 6 months and who assist to a third level health care institution in Bucaramanga, Colombia. The patient version of the quality of life scale and the Instrument to measure the facts that influence the adding of pharmacological and non-pharmacological treatments on people with high risk of cardiovascular diseases were employed. Descriptive statistic and the linear correlation coefficient of Pearson were utilized into analysis. Results: Women were majority in the participants’ sample, older than 60, from low social strata, housewives, mainly affected with breast, cervix, and skin cancer; 15 % of illiteracy was observed. Quality of life showed an average of 104.17 (SD 16.71). 51% were ranked under low risk and 41.75 were ranked medium risk in order to avoid adherence. A weak positive relation was found between the two variables, r= 232 p=0.003.Discussion: Linear correlation between the variables is less than in other conditions of chronic non-communicable and chronic infectious diseases. Conclusions: There is a weak relation between the global sum of the variables and the dimensions of each one.

Calidad de vida y adherencia al tratamiento de personas con enfermedad crónica oncológica / Quality of life and adherence to treatment of people with chronic cancer disease

El cáncer es un fenómeno de salud que afecta las diferentes esferas del ser humano, familiares y sociales. La experiencia del cáncer afecta las dimensiones de la Calidad de vida (Física, psicológica, social y espiritual); la adherencia al tratamiento oncológico es un asunto poco descrito en la literatura científica, sin embargo, este aspecto puede guardar relación con los niveles de calidad de vida de personas con enfermedad crónica oncológica, sobre todo en los primeros meses del diagnóstico. Objetivo: determinar la relación existente entre la Calidad de Vida de personas con enfermedad crónica oncológica y los grados de riesgo para la Adherencia al Tratamiento Oncológico. Método: estudio descriptivo, de correlación, abordaje cuantitativo y corte transversal. Participaron 158 personas con enfermedad crónica oncológica diagnosticadas entre 0 y 6 meses que asisten a una institución de tercer nivel de atención en salud de Bucaramanga, Colombia. Se aplicó la Escala de Calidad de vida versión paciente y el Instrumento para Evaluar los Factores que Influyen en la Adherencia a los Tratamientos Farmacológicos y no Farmacológicos en Pacientes con Riesgo de Enfermedad Cardiovascular. Análisis: se utilizó estadística descriptiva y el coeficiente de correlación lineal de Pearson. Resultados: la mayoría de la muestra fueron mujeres, mayores de 60 años, de estratos bajos, dedicadas al hogar, principalmente con cáncer de mama, cérvix, piel; se observó analfabetismo en el 15%. La Calidad de vida mostro media de 104.17 (DE 16.71). El 51% se ubicó en bajo riesgo y 41.75 riesgo medio para no adherirse. Se encontró relación débil positiva entre las dos variables r=,232 p=0,003. Conclusión: hay relación débil entre la sumatoria global de las variables y las dimensiones de cada variable.

Cancer is a health phenomenon that affects the different spheres of the human being, as well as family and social issues. Cancer experience also affects the dimensions of quality of life (physical, psychological, social and spiritual); the adding of an oncological treatment is a matter that has not been described in the scientific literature, however this aspect can be related to the levels quality of life of the people suffering from chronic oncologic diseases, mainly during the first months of diagnosis. Objective: Determine the existent relationship between the quality of life of the people suffering from chronic oncologic diseases and the degrees of risk for the adding to an oncological treatment. Method: correlative descriptive research, quantitative boarding and cross-cutting. 158 participants with chronic diseases that were diagnosed with a life expectancy between 0 and 6 months and who assist to a third level health care institution in Bucaramanga, Colombia. The patient version of the quality of life scale and the Instrument to measure the facts that influence the adding of pharmacological and non-pharmacological treatments on people with high risk of cardiovascular diseases were employed. Analysis: Descriptive statistic and the linear correlation coefficient of Pearson were utilized. Outcomes: Women were majority in the participants' sample, older than 60, from low social strata, housewives, mainly affected with breast, cervix, and skin cancer; 15 % of illiteracy was observed. Quality of life showed an average of 104.17 (SD 16.71). 51% were ranked under low risk and 41.75 were ranked medium risk in order to avoid adherence. A weak positive relation was found between the two variables, r=,232 p=0.003. Conclusion: There is a weak relation between the global sum of the variables and the dimensions of each one.